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Tvrd povez, 281 strana, 1999 godina Izdavac: Birkhauser Verlag, Basel, Boston, Berlin Knjiga lepo ocuvana P2/3 In this book, emphasis is placed on the scientific background leading to the discovery of valproate, and its clinical development into one of the most widely used antiepileptic drugs, a milestone in drug therapy. It reviews the state of the drug, and looks at hypotheses on its mechanisms of action, its metabolism into pharmacologically active metabolites, its unique distribution characteristics, and its various clinical uses Valproic acid was first synthesized in 1882 by Burton, but there was no known clinical use until its anticonvulsant activity was fortuitously discovered by H. Meunier in 1963 in the laboratory of G. Carraz. The first clinical trials of the sodium salt of valproate were reported in 1964 by Carraz. It was marketed in France in 1967 and was released in the United States in 1978 for the treatment of epilepsy. Since then, valproate has established itself worldwide as a major antiepileptic drug against several types of seizures. Clinical experience with valproate has continued to grow in recent years, including use of valproate for diseases other than epilepsy, for example in bipolar disorders and migraine. In this book, emphasis is placed on the scientific background leading to the discovery of valproate and its clinical development into one of the most widely and successfully used antiepileptic drugs, a real milestone in drug therapy. The current state of knowledge of valproate is reviewed by experts in the field, including new hypotheses on its mechanisms of action, its metabolism into pharmacologically active metabolites, its unique distribution characteristics, its undesirable hepatotoxic and teratogenic adverse effects, and its various clinical uses. The monograph is aimed at a broad readership, particularly neurologists, psychiatrists and basic scientists working in the field of epilepsy research. Furthermore, the book also deals with structure-activity relationships of valproate as well as of its metabolites and analogs and should therefore attract researchers working in medicinal chemistry.
Veoma lepe,kvalitetne,moderne baletanke,plave sa belim tačkicama i ukrasnom mašnom od kamenčića šljaštećih,efektnih.Unutrašnjost je od kože a spolja su presvučene platnom koje podseća na teksas.Odlične su čvrste,ne krive se ,visok kvalitet. Veličina piše 37,dužina gazišta 23,Potpuno očuvane! Pogledajte i moju ponudu na alexiss kupindo!
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Zenske kozne cipele ART-1408 na anatomskom flexy djonu sa koznim anatomskim uloskom.Veoma udobna mekana i lagana.Raspoloziva u leopard boji. RASPRODAJA zbog prestanka prodaje ovog artikla koji se nece vise nabavljati (ZOT- clan 37 tacka 3) vazi od 21.07 do isteka zaliha.
Nove zenske cipele-baletanke marke SeaStar. Italijanske. Odlicne zenske baletanke italijanske marke SeaStar. Odlicno uradjene, prelepe zenske cipele, imaju ukras u zlatnoj boji napred na licu. Cipele za sve prilike, mogu se nositi svaki dan, a idealne su za posebne prilike i svecanosti, nesto sto bi svaka devojka i dama trebalo da poseduje. Izuzetne zenske baletanke u beloj boji sa zlatnim ukrasom su potpuno nove sa svojom originalnom kutijom. Boja: Bela sa zlatnim ukrasom. Velicina: 36. Sastav: lice vestacka koza, djon poliuretan, postava vestacka koza. Dimenzije: Duzina gazista 23 cm Visina djona na peti 1,2 cm
Minerals in Animal and Human Nutrition Comparative Aspects to Human Nutrition (Animal Feeding and Nutrition) Lee Russell McDowell Acedemic Press Printet in The USA 1992g Knjiga na engleskom Tvrd povez,524 str. Knjiga odlicno ocuvana,kao nova. -`This book presents concise, up-to-date information on mineral nutrition for livestock and poultry, as well as comparative aspects with laboratory animals and humans. Chapters are organized by established and most common minerals and present information on each mineral`s properties, distribution, and natural sources, as well as their requirements, metabolism, functions, deficiencies, and toxicity in various animals`... vr429
Naziv : Pedijatrija Autori : Duško Mardešić i suradnici ISBN :978-953-0-31592-1 Br, Strana :1168 Povez : Tvrd Jezik: HR Status Izdanje : prestampano ,2016 Izdavač: Školska knjiga Knjiga je u odlicnom stanju, Stanje kao na slici Molim vas pišite ili poručujte na Viber , WhatsApp , Sms ili Mobilni Slanje : Slanje Postexpresom, plaćanje pouzećem ili lično preuzimanje
Vitamins in Animal Nutrition Comparative Aspects to Human Nutrition Lee Russell McDowell Academic Press printet in The USA Knjiga na engleskom 1989g. Tvrd povez,manji tragovi ostecanja na korici i predlistu,ostalo odlicno ocuvano. -`Vitamins in Animal Nutrition presents concise, up-to-date information on vitamin nutrition for livestock and poultry; comparisons with vitamin use in human nutrition are also presented. This book describes the basic chemical, metabolic, and functional role of vitamins and vitamin supplementation. A wealth of photographs illustrate the nutritional aspects of vitamin deficiencies and excesses in livestock, along with their concomitant conditions. This authoritative reference is of interest to professionals in animal nutrition and the livestock industry and is suitable as a graduate-level text on vitamin nutrition in animals.`... vr429